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Вилдегра — инструкция по применению, дозы, побочные действия.

Вилдегра Uses, Dosage, Side Effects, Food Interaction and all others data. Вилдегра Citrate belongs to a group of medicines called phosphodiesterase type-5 (PDE-5) inhibitors. Вилдегра at recommended doses has no effect in the absence of sexual stimulation. Вилдегра causes mild and transient decreases in systemic blood pressure which, in the majority of cases, do not translate into clinical effects .

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Вилдегра Citrate is used for the treatment of Erectile Dysfunction. Вилдегра is also used to associated treatment for these conditions: Erectile Dysfunction, NYHA Functional Class II-III Pulmonary arterial hypertension, Premature Ejaculation, Symptomatic pulmonary arterial hypertension (PAH) Вилдегра is an oral therapy for erectile dysfunction . Вилдегра is a potent and selective inhibitor of c GMP specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum, where PDE5 is responsible for degradation of c GMP .

Вилдегра has a peripheral site of action on erections . Вилдегра has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue . Вилдегра, therefore, increases c GMP within pulmonary vascular smooth muscle cells resulting in relaxation .

Вилдегра dosage The usual starting dose of Вилдегра is 50 mg once daily. Вилдегра may takes longer time to work if you take it with a heavy meal. Like all medicines, Вилдегра can cause side effects although not everybody gets them. The side effects reported in association with the use of Вилдегра are usually mild to moderate and of a short duration. All medicines including Вилдегра can cause allergic reactions.

Вилдегра, 100 мг, таблетки пролонгированного действия."Вилдегра, 100 мг, таблетки пролонгированного действия.

Contact with doctors immediately if experiences any of the following symptoms after taking Вилдегра: sudden wheeziness, difficulty in breathing or dizziness, swelling of the eyelids, face, lips or throat. Вилдегра was not carcinogenic when administered to rats for 24 months at a dose resulting in total systemic drug exposure (AUCs) for unbound sildenafil and its major metabolite of 29- and 42- times, for male and female rats, respectively, the exposures observed in human males given the Maximum Recommended Human Dose (MRHD) of 100 mg . Вилдегра was not carcinogenic when administered to mice for 18-21 months at dosages up to the Maximum Tolerated Dose (MTD) of 10 mg/kg/day, approximately 0.6 times the MRHD on a mg/m2 basis .

Вилдегра was negative in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes and in vivo mouse micronucleus assays to detect clastogenicity . Вилдегра should not be generally used in men for whom sexual activity is inadvisable because of their underlying cardiovascular status.   Вилдегра has systemic vasodilatory properties (mean maximum decrease of 8.4/5.5 mm Hg).  

aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with severely impaired autonomic control of blood can be particularly sensitive to the actions of vasodilators including Вилдегра. There is no controlled clinical data on the safety or efficacy of Вилдегра in Patients who have suffered from a myocardial infarction, stroke, or life-threatening arrhythmia within the last 6 months.

Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of Вилдегра. Вилдегра tablets may interfere with some medicines, especially those used to treat chest pain. In the event of a medical emergency, you should tell the healthcare professional treating your condition that you have taken Вилдегра and if you did, do not take Вилдегра with other medicines unless your doctor tells you can.

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You should not take Вилдегра if you are taking medicines called nitrates as the combination of these products may cause a potentially dangerous decrease in your blood pressure. You should not take Вилдегра if you are using any of the drugs known as nitric oxide donors such as amyl nitrite as the combination may also lead to potentially dangerous decrease in your blood pressure. If you are taking medicines known as protease inhibitors, such as for the treatment of HIV, your doctor may start you on the lowest dose (25 mg) of Вилдегра. Certain patients have experienced these symptoms when taking Вилдегра with alpha-blocker. This is most likely to occur within 4 hours after taking Вилдегра. In order to reduce the likelihood of these symptoms occur,you should be on a regular daily dose of your alpha-blocker before you start Вилдегра. Your doctor may start you on a lower dose (2S mg) of Вилдегра if you have hypotension (avoid if systolic blood pressure below 90 mm Hg), recent stroke, unstable angina & myocardial infarction.

Drinking alcohol can temporally impair your ability to get an erection, to get the maximum benefit from your medicine; you are advised not to drink excessive amounts of alcohol before taking Вилдегра. Вилдегра 50 mg and vardenafil 20 mg reportedly did not potentiate the hypotensive effect of alcohol in healthy volunteers with mean maximum blood alcohol levels of 0.08% and in healthy volunteers administered alcohol at a dose of 0.5 g/kg, respectively.